Disclaimer: GloboMechanic.com is reader-supported. When you purchase through links on this site, we may earn an affiliate commission at no extra cost to you.

10 Best Methylfolate Supplement in 2022

Finding the best methylfolate supplement is not an easy task. There are hundreds of similar products on the market which can cater to your needs, but only a few of them stand out from the rest. We have researched hundreds of customer reviews and feedback from all around the web before we made our top 10 list of methylfolate supplement. We did the heavy lifting, and made the process easy for you. So without further ado, let’s get into the list.

10 Best Methylfolate Supplement – Top Picks of 2022

Product 1
Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical Grade Methylcobalamin (B12), Niacin, B1, B2 & B6. Works Synergistically for Max Results-3 Month Supply
  • ♥ Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
  • ♥ Developed as most optimally absorbed and bioavailable 5-MTHF
  • ♥ Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health
  • ♥ Suitable for people who are diagnosed with MTHFR mutation
  • ♥ To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the quality and purity of each batch. All Made in USA.
On SaleProduct 2
NOW Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets
  • CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.*
  • METABOLICALLY ACTIVE FOLATE*/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
  • CERTIFICATIONS/CLASSIFICATIONS: Non-GMO, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
  • Packaged in the USA by a family owned and operated company since 1968
On SaleProduct 3
Jarrow Formulas Methyl Folate 400 mcg - 60 Veggie Caps - Highly Biologically Active Form of Folate - 4th Generation Folic Acid Technology - 60 Servings
  • Methyl Folate - Jarrow Formulas Methyl Folate is a highly biologically active form of folate. Due to the body’s limited ability to transform synthetic folic acid into the active form of folate, supplementation with 5-MTHF is highly preferable.
  • Quatrefolic - Featuring 4th generation development in folate delivery, our patent-pending technology formula features increased stability and bioavailability.
  • Benefits - Healthful diets with adequate folate may reduce the risk of having a child with a brain or spinal cord birth defect.*
  • Convenient Veggie Capsules - Each veggie capsule delivers 400 micrograms (mcg) of methyl folate. Take 1 capsule per day, with or without a meal, or as directed by your qualified healthcare professional.
  • Superior Nutrition & Formulation - The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements. Our customers can be assured of purity, value, and potency.
On SaleProduct 4
MethylPro 15mg L-Methylfolate (90 Capsules) - Professional Strength Active Methyl Folate, 5-MTHF Supplement for Mood, Homocysteine Methylation + Immune Support, Gluten-Free with No Fillers
  • The Leader In Faster, Active Folate - Approximately half the US population may have difficulty converting folate into its active form. MethylPro is the leading nutraceutical line featuring l-methylfolate, the most advanced form for better results.*
  • Professional Strength - Many methylfolate products contain mcg or 1mg amounts. MethylPro offers a range of potent therapeutic doses. This 15 mg dose is our strongest, for a difference you can feel.*
  • Brain & Mood Support - Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, energy, hormones and mood stability. This is the only form of folate to cross the blood-brain-barrier.*
  • Promotes Cardiovascular & Nerve Health - May help promote heart health & healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.*
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. The only additional ingredient is the amino acid glycine. This product is free of soy, gluten, dairy, eggs, and nuts. Take only as directed under the supervision of a Physician.*
On SaleProduct 5
Jarrow Formulas Methyl B-12 & Methyl Folate - 100 Chewable Tablets, Lemon - Bioactive Vitamin B12 & B9 - Supports Energy Production, Brain Function & Metabolism - Gluten Free - 100 Servings
  • Bioactive B Vitamins - Methyl B-12 & Methyl Folate provides methylcobalamin (methyl B-12) & methyl folate, which are the biologically active forms of vitamin B12 and B9, plus pyridoxal-5-phosphate (P5P), the coenzyme form of vitamin B6.
  • Full-Body Benefits - This Jarrow Formulas supplement combines the active forms of these vitamins to support energy production, brain function, DNA & neurotransmitter synthesis, and amino acid metabolism.*
  • Homocysteine Metabolism - Methyl B-12 and methyl folate facilitate the metabolism of homocysteine into methionine, while P5P facilitates the metabolism to cysteine.
  • Convenient Chewable Tablet - Each lemon-flavored chewable tablet delivers 1.5 mg of vitamin B6, 680 mcg of folate, and 1000 mcg of vitamin B12. Our formula contains no wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.
  • Superior Nutrition & Formulation - The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements. Our customers can be assured of purity, value, and potency.
Product 6
L Methyl Folate 15mg Plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports Mood, Homocysteine Methylation, Cognition (60 Capsules)
  • PROFESSIONAL STRENGTH: Provides clinically validated dosage of 15mg L Methyl folate in the 5-MTHF calcium salt form. This is the most active form of Folate.
  • ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is crucial for those with methylation issues that cannot properly process folic acid.
  • BRAIN, MOOD & ENERGY SUPPORT: Essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.*
  • CARDIOVASCULAR, NITRIC OXIDE & NERVE SUPPORT: Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.
Product 7
L-Methylfolate 15mg (120 Vegan Capsules) - Max Absorption and Potency - L Methyl Folate Supplement, 5-MTHF for Folic Acid Deficiency - Non-GMO, Gluten Free
  • GREAT VALUE OF LMETHYLFOLATE - Our Zenavea supplements offer you a great value with 120 capsules. Each capsule serves 15mg of l 5 mthf supplement , the most on the market and the recommended dose.
  • THE LMETHYLFOLATE 15 MG TABLET YOU NEED - Folate is a b vitamins found in some food. With commun and current diet, people might present deficiencies in folic acid and this is where folate supplement for women and men can help you.
  • OPTIMIZED FORMULA - Our l methylfolate 15mg contains an optimized formula to give the best results. It is non bioengineered and contains NO GMO, NO allergens (no fish, no egg, no milk, no soy, no gluten, no sugar, no wheat and so on). It is safe to use.
  • GET THE BEST BENEFITS - Our tablets contain folic acid methylfolate that will help support the synthesis of molecules which is important for people with folate deficiency. It will improve your overall wellbeing and support your nerve function and brain. Its is also considered a mood support supplement, immune support supplement, brain support supplement, and in some cases depression supplements*
  • TRUSTED ZENAVEA BRAND - Zenavea is a trusted brain with experience in food supplement. Made in the USA, our formula follows strict quality standards to be GMP certified. Our l--mthf's pills capsules are vegan, sugar free, and gluten free. These really are the best l methyfolate capsules on the market! *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Product 8
Methyl Folate 1000 mcg | 200 Capsules | 5-MTHF | Folic Acid Supplement | Non-GMO, Gluten Free Methylfolate | by Horbaach
  • ESSENTIAL NUTRIENT: Methyl Folate is the active, more bioavailable form of the B-Vitamin Folic Acid
  • CONVENIENT FORM: Delivers 1000 mcg of this important nutrient in Quick-Release capsules
  • EXPERTLY CRAFTED: Specially formulated supplement derived from high-quality sourcing standards
  • HORBAACH MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
  • NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Lactose, Soy, Artificial Color & Flavoring & NON-GMO
Product 9
MD. Life L-Methylfolate 5 mg - Active Folate 5 Mthfr Support Supplement Professional Strength Methyl Folate - Essential Amino Acids & Brain Supplement- 90 Vegan Capsules
  • ACTIVE FOLATE THAT WORKS - This L methylfolate 5mg formula contains the ingredients necessary for your body to properly utilize folic acid, also known as a complex b9 vitamin. Unlike folic acid, the synthetic form of vitamin B9, methylfolate is the already converted form of folate people can easily use without the need of the MTHFR enzyme.*
  • SYNTHESIS AND REPAIR* - Methylfolate 5 mg, the most active form, is essential in the production and maintenance of new cells.*
  • THIRD PARTY TESTED FOR PURITY - All our brain supplements undergo extensive third -party testing to maintain the highest level of quality and purity in the manufacturing of our products. Having third party certification means these products comply with specific standards set for safety, quality and performance. These products are also made and packaged in the USA.
  • MOOD & BRAIN SUPPORT* – MD Life’s Methyl folate 5mg is a great choice for mood support. Sleep, concentration, energy, mood stability and hormone support are assisted by methylfolate.
Product 10
Life Extension Optimized Folate (L-Methylfolate) – Supports Heart & Brain Health – Non-GMO, Gluten-Free, Vegetarian –1700 mcg DFE — 100 Vegetarian Tablets
  • BIOLOGICALLY ACTIVE FOLIC ACID — Our Optimized Folate formula promotes both cardiovascular and cognitive health with 1700 mcg of folate in the form of 5-MTHF (L-Methylfolate), the metabolically active form of folic acid.
  • WHY FOLATE? – Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with heart and brain health. Folate, a B vitamin, helps maintain homocysteine levels already within normal range. However, not everyone can efficiently convert folate to its biologically active form. Our formula provides 5-MTHF, so you don’t have to.
  • HEART & BRAIN-FRIENDLY NUTRIENT – Because folate helps inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular biomarker. Since healthy homocysteine levels have been associated with cognitive health, getting enough folate is especially crucial for individuals who want to maintain brain health.
  • INGREDIENTS MATTER - Sourced using only the finest raw ingredients with the purity and potency your body deserves. The majority of our products are non-GMO, gluten-free, and manufactured in the USA—and a Certificate of Analysis is available for every product we produce.
  • LIVE YOUR HEALTHIEST LIFE - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. Our formulations are created using the ingredients and dosages used in the studies that inspired them, ensuring that maximum bioavailability and efficacy is achieved.

Best Methylfolate Supplement Buying Guide

Last year alone, we spent nearly three hundred billion dollars on more than two million products. That’s a ton of money being pumped into the marketplace. But how can you best guarantee you will get your hands on the best products? That’s why it’s important to have the proper advice before spending your money on methylfolate supplement. That’s exactly what this guide is for. We’ve explained all the important aspects to look for and compiled all our findings into a comprehensive list, so you can easily access the information that you need.

  • Quality of the product: Quality is something that you should always be concerned about when purchasing the methylfolate supplement. These days you can find so many products that are of bad quality that it is extremely difficult to tell the good ones from the bad ones.
  • Features of the product: Product features tell you if it will suit your needs and help you to make the right choice. However, features are not all the criteria for choosing a product. You also need to make sure that it works as described.
  • Price of the product: Price is another essential factor you should consider when you are shopping for methylfolate supplement. Think about how much you need the product and compare it to the price you are willing to pay. Try to choose the item that you can afford and avoid paying overpriced products.
  • Existing customer reviews: When buying new methylfolate supplement, you should always look for customer reviews. Because customer reviews tell you what other customers think about the product, they help you avoid making costly mistakes.
  • Online marketplace: What marketplace you’re buying the methylfolate supplement from is going to make a difference. If you’re buying it off Amazon, make sure the seller has a good reputation with a comparatively lower Best Seller Rank (BSR) in the category where the product is listed. Please don’t buy it off a random person that only has a few reviews.

Final Words

So now you have all the information on the best methylfolate supplement, and it’s your time to pick the suitable methylfolate supplement for yourself. You can choose from our list without any hesitation. And don’t forget, you can’t go wrong with our recommendation.